General Surgery

Question 1. Types of shock.

Answer:

Various Types Of Shock Are As Follows:

Question 2. Septic shock.

Answer:

Aetiology:

• Release of endotoxin by gram-negative organisms.
• Severe septicaemia.
• Peritonitis.
• Meningitis

Haemorrhage shock and blood transfusion Q&A

Question 3. Neurogenic shock.

Answer:

Neurogenic Shock Causes:

• Paraplegia, quadriplegia.
• Trauma to the spinal cord.
• Spinal anaesthesia.

Neurogenic Shock Clinical Features:

• Skin remains warm, pink and well-perfused.
• Urinary output – normal.
• Heart rate is rapid.
• Blood pressure is decreased.

Question 4. Cardiogenic shock.

Answer:

Cardiogenic Shock Causes:

• Injury to the heart
• Myocardial infarction.
• Cardiac arrhythmia.
• Congestive cardiac failure.

Cardiogenic Shock Clinical Features:

• Initially
  • Skin is pale and cool.
  • Urine output reduced.
• Later
  • Rapid pulse.
  • Hypotension
  • Distended neck veins.
  • The liver is enlarged.
  • The heart becomes enlarged.

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Question 5. Hypovolaemic shock.

Answer:

Hypovolaemic Shock Causes:

• Blood and plasma loss
• Electrolyte loss.

Question 6. Crush Syndrome.

Answer:

Crush Syndrome

It is a symptom complex in which a portion of the body becomes crushed due to a heavy weight falling on that portion and is kept there for some time to crush all the tissues in that portion.

Crush Syndrome Causes:

• Earthquakes
• Mine injuries
• Air raids
• Collapse of the building.
• Use of a tourniquet for a longer period.

Crush Syndrome Clinical Features:

• Extravasation of blood into muscles.
• Muscles are crushed and swollen.
• Acute renal tubular necrosis.
• Reduced urinary output.
• Tense and painful extremities.

Crush Syndrome Treatment:

• Application of a tourniquet.
• Parallel incisions are made to relieve tension.
• Administration of intravenous fluid.
• Catheterisation of the bladder.
• Hemodialysis is a severe condition.

Short questions on haemorrhage and shock

Question 7. Hypokalaemia.

Answer:

Hypokalaemia

Potassium deficiency in the diet is called hypokalemia.

Hypokalaemia Causes:

• Following trauma.
  • Starvation
  • Loss of gastrointestinal secretion.

Hypokalaemia Clinical features:

• Gradual onset of drowsiness.
• Slow and slurred speech.
• Irritability.
• Muscular hypotonia and weakness.
• Absence of deep reflexes.
• Slow pulse rate.
• Diminished intestinal motility.
• Low BP.
• Skin remains warm and dry.

Hypokalaemia Treatment:

• Replacement of potassium deficit.

Question 8. Acidosis.

Answer:

Acidosis

An increase in pH leads to acidosis.

Acidosis Types:

1. Metabolic acidosis.
   • In it, there is a gain or retention of fixed acids or a loss of base.
   • Cause:
     • Diabetic acidosis.
     • Lactic acidosis.
     • Renal insufficiency.
     • Rapid transfusion of bank blood.
     • Diarrhoea.
   • Clinical Features:
     • Increase in rate and depth of breathing.
     • Rapid and noisy respiration.
     • Raised pulse rate and blood pressure.
     • Urine becomes strongly acidic.
   • Treatment:
     • Administration of Ringer’s lactate solution.
2. Respiratory acidosis.
   • Causes:
     • Lung disorders.
     • Peritonitis
     • Crush injury.
     • Depressed respiratory centre.
     • Airway obstruction.

Acidosis Clinical Features:

• Slow rise in BP.
• Abnormal respiration.
• Restlessness.
• Hypertension
• Tachycardia.

Acidosis Treatment:

• Mechanical ventilation
• Endotracheal intubation.
• Avoid over-sedation and over-use of muscle relaxants.

Question 9. Haemorrhage.

Answer:

Haemorrhage

Haemorrhage is defined as the escape of blood from blood vessels.

Haemorrhage Classification:

1. Based on the bleeding haemorrhage.
   • External and internal.
   • Arterial, venous or capillary.
2. Based on the time of appearance.
   • Primary – Secondary – Reactionary.

Blood transfusion questions and answers

Question 10. Secondary Haemorrhage.

Answer:

Secondary Haemorrhage

Secondary Haemorrhage is a bleeding that usually occurs after 7-14 days of injury.

Secondary Haemorrhage Causes:

• Infection.
• Sloughing part of the arterial wall.

Secondary Haemorrhage Clinical features:

• Preceded by a warning, haemorrhage staining the dressings.
• Followed by moderate to severe haemorrhages.

Secondary Haemorrhage Types:

• Externally – example: at the operation site of haemorrhoids- tomy.
• Internally, Example: haematemesis following peptic ulcer operation.

Question 11. Hemophilia.

Answer:

Hemophilia

Haemophilia is an X-linked recessive disorder of coagulation factors.

Haemophilia Types:

1. Haemophilia A-classic haemophilia – due to factor 8 deficiency.
2. Haemophilia Christmas disease -due to factor 9 deficiency.
3. Von Willebrand’s disease is due to a deficiency of von Willebrand factor.

Haemophilia Clinical features:

• Easy bruising
• Prolonged bleeding.
• Spontaneous bleeding into subcutaneous tissue.
• GIT bleeding.
• Hypotaxis.
• Recurrent haemarthrosis.
• Hematuria.
• Intracranial haemorrhage.

Question 12. Disseminated intravascular coagulation (DIC)

Answer:

Disseminated intravascular coagulation (DIC)

Disseminated intravascular coagulation is a complex thrombo-hemorrhagic disorder occurring as a secondary complication in some systemic diseases.

Pathogenesis:

• Includes

1. Activation of coagulation
2. Thrombotic phase
3. Consumption phase.
4. Secondary fibrinolysis.

Question 13. Blood groups.

Answer:

Blood groups

Blood groups are classified based on the presence or absence of specific agglutinogen or antigen on the surface of RBC.

Major blood groups are:

1. ABO system

2. Rh blood group.

• • Rh factor is an antigen present in RBC.
  • Persons having the D antigen are called Rh-positive.

Question 14. Rh factor.

Answer:

Rh Factor

• Rh factor is an antigen present in RBCs.
• Rh factor was first discovered by Landsteiner and Weiner in rhesus monkey.
• Rh factor is detected only in RBCs
• Rh factor is inherited from both parents as homozygous positive DD, heterozygous negative Dd or homozygous negative dd.
• Rh Antibody is absent in plasma.
• But its production can be evoked by.
  • Transfusion with Rh-positive blood.
  • The entrance of Rh-positive blood from the foetus into the circulation of the Rh-negative mother.

Types of shock short answer questions

Question 15. Blood Transfusion.

Answer:

Blood Transfusion

Blood Transfusion is a process of transferring blood or blood-based products from one person into the circulatory system of another.

Blood Transfusion Types:

1. Typical stored CPD blood from the blood bank.
2. Filtered blood filtered through a membrane with 40 |im pores.
3. Warm blood is used in cardiopulmonary operations.
4. Autotransfusion – preserving and then transfusing one’s blood.
5. Replacement transfusion – used in newborns.

Question 16. Indications of blood transfusion.

Answer:

Acute Haemorrhage.

• During operations, preoperatively and postoperatively.
• Anaemia.
• Malnutrition.
• In severe burns.
• In coagulation disorders.
• In erythroblastosis fetalis.
• During chemotherapy.

Question 17. Complications of blood transfusion.

Answer:

Complications Of Blood Transfusion

1. Transfusion reactions
   • Incompatibility
   • Pyrexia reactions
   • Allergic reactions
   • Sensitisation to leucocytes and platelets
2. Transmission of diseases
   • Serum hepatitis
   • AIDS
3. Reactions caused by massive transfusion.
   • Acid-base imbalance.
   • Hyperkalaemia.
   • Citrate toxicity.
   • Hypothermia.
   • Failure of coagulation.
4. Complications of over-transfusion.
   • Congestive cardiac failure.
5. Other complications.
   • Thrombophlebitis
   • Air embolism.

Question 18. Types of haemorrhage

Answer:

Types of Haemorrhage

1. According to the source
   • External haemorrhage – seen externally
   • Internal haemorrhage – not seen externally
2. According to the vessels involved
   • Arterial haemorrhage – haemorrhage coming out of the artery
   • Venous haemorrhage – haemorrhage coming out of a vein
   • Capillary haemorrhage – haemorrhage coming out of the capillary
3. According to the time of appearance
   • Primary haemorrhage – at the time of injury
   • Reactionary haemorrhage – within 24 hours of injury
   • Secondary haemorrhage – after 7-14 days of injury

MCQs on haemorrhage and shock

Question 19. Reactions to blood transfusion

Answer:

Reactions To Blood Transfusion

Haemorrhage Shock And Blood Transfusion Important Notes

1. Classification Of Haemorrhage
   • Based on the nature of the vessel involved
     • Arterial
     • Venous
     • Capillary
   • Based on the timing of the haemorrhage
     • Primary
     • Reactionary
     • Secondary
   • Based on the duration of the haemorrhage
     • Acute
     • Chronic
   • Based on the source of the haemorrhage
     • External
     • Internal
2. Methods Of Measuring Blood Loss
   • Weighing swab
   • Measurement of swelling in a closed fracture
   • Measuring a blood clot
3. Methods To Stop Bleeding
   • Rest
   • Pressure and packing
   • Ligation of vessels
4. Hemophilia
5. Shock
   • Definition
     • Shock is a condition in which circulation fails to meet the nutritional needs of the cells and fails to remove the metabolic waste products
   • Classification
     • Haematogenic or hypovoJaernic shock
     • Traumatic shock
     • Neurogenic shock
     • Cardiogenic shock
     • Septic shock
     • Miscellaneous
       • Anaphylactic shock
6. Blood Transfusion
   • Indications
     • Acute haemorrhage
     • Major surgery
     • Deep burns
     • Pre-operative and post-operative in anaemia
     • In malnutrition
     • In coagulation disorders
     • In erythroblastosis details
     • During chemotherapy in malignant diseases
   • Complications
     • Transfusion reactions
       • Incompatibility
       • Pyrexia reactions
       • Allergic reactions
     • Transmission of diseases
     • Reactions caused by massive transfusion
       • Acid-base imbalance
       • Hyperkalaemia
       • Citrate toxicity
       • Hypothermia
       • Failure of coagulation
     • Complications of over-transfusion
       • Congestive cardiac failure
     • Other complications
       • Thrombophlebitis
       • Air embolism
7. Blood Products
   • Plasma and its derivatives
     • Fresh frozen plasma
     • Platelet-rich plasma
     • Fibrinogen
     • Albumin
     • Cryoprecipitate
   • Synthetic solution
     • Dextran
     • Gelatin
     • Hydroxyethyl starch
     • Fluorocarbons

Haemorrhage shock and blood transfusion notes

Haemorrhage Shock And Blood Transfusion Short Essays

Question 1. Vasovagal shock.

Answer:

Vasovagal Shock

• Vasovagal shock is a type of neurogenic shock.

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Pathophysiology:

Vasovagal Shock Clinical features:

• Reduced blood flow to the brain.
• Cerebral hypoxia.
• Bradycardia.
• Hypotension
• Unconsciousness
• Pallor

Vasovagal Shock  Treatment:

• Place the patient flat or in head low position.
• Maintain airway
• Use of 4 atropine.

Notes on haemorrhage and its classification

Question 2. Reactionary bleeding.

Answer:

Reactionary Bleeding

Reactionary bleeding is defined as bleeding that occurs within 24 hours of injury or operation.

Reactionary Bleeding Causes:

• Dislodgement of a blood clot.
• Slipping of ligatures.

Reactionary Bleeding  Precipitating Factors:

• Rise in blood pressure
• Restlessness.
• Coughing
• Vomiting
• A rise in venous pressure.

Question 3. Haemophilia.

Answer:

Haemophilia

• Haemophilia is a sex-linked inherited disorder.
• Haemophilia is carried by a recessive gene.
• Transmitted through female carriers.

Haemophilia Cause:

• Lack of factor 8, a coagulation factor.

Haemophilia Clinical features:

• Bleeding after mild trauma.
• Repeated haemorrhages into joints.
• Spontaneous retroperitoneal bleeding.
• Severe abdominal pain and tenderness.
• Haematuria.
• Permanent damage to the articular cartilages and articular surfaces.
• Disorganisation of the joints.

Haemophilia Treatment:

• Periodic infusion of cryoprecipitate.
• Transfusion of fresh blood or fresh frozen plasma.

Shock types and management notes

Haemorrhage Shock And Blood Transfusion Viva Voce

1. Albumin is not used in chronic renal disease, chronic liver disease and to treat malnutrition
2. Cryoprecipitate is a rich source of factor 8
3. Fluorocarbon is considered to be a red cell substitute
4. Blood is stored in blood banks at 4°C
5. Cold citrate-containing blood changes storage
6. Blood is separated into individual components to optimize therapeutic potency
7. Styptics are local hemostatic agents used to stop bleeding from the local approaching site
8. Hypotension manifests when blood loss exceeds 30%

Haemorrhage Shock And Blood Transfusion Long Essays

Question 1. Classify shock. Describe the pathophysiology, clinical features and management of shocks.

Answer:

Shock:

• Shock is a condition in which circulation fails to meet the nutritional needs of the cells and fails to remove the metabolic waste products.
• It is characterised by hypoperfusion and severe dysfunction of vital organs.

Shock Classification:

1. Haematogenic or hypovolaemic shock.
   • Occurs due to loss of blood, plasma or body water and electrolytes.
   • Caused by haemorrhage, vomiting, diarrhoea, dehydration, etc.
2. Traumatic shock.
   • Caused by major fractures, crush injuries, burns, extensive soft tissue injuries and intraabdominal injuries.
3. Neurogenic shock.
   • Caused by paraplegia, quadriplegia, trauma to the spinal cord and spinal anaesthesia.
4. Cardiogenic shock.
   • Caused by injury to the heart, myocardial infarction or congestive cardiac failure.
5. Septic shock.
   • Occurs due to gram-negative septicaemia.
6. Miscellaneous types – includes:
   • Anaphylactic shock.

Physiology: It can be described as 2 processes.

1. Reduced effective circulating volume.
   • May result in either.
     • By actual loss of blood volume or
     • By decreased cardiac output.
2. Tissue anoxia.

Haemorrhage shock and blood transfusion long essay

Shock Clinical features:

Management: AIMS:

• To increase cardiac output.
• To improve tissue perfusion to vital organs.

Shock Treatment:

1. Maintenance.
   • Maintain a patent airway and oxygen.
   • Head position – At a low position with the face turned to one side
2. Control of haemorrhage.
   • Done by elevation, compression bandages or by ligation of blood vessels.
3. Extracellular fluid replacement.
   • Nonsugar, nonprotein crystalloid is preferred.
   • Normal saline or Ringer’s lactate should be started first.
4. Correct acid-base disturbance.
5. Drugs.

Long essay on types of shock and management

Question 2. Describe the pathophysiology, clinical features and treatment of septic shock.

Answer:

Septic Shock:

• Septic shock is caused by to release of endotoxin in blood, mostly by Gram-negative organisms.
• Occurs in cases of severe septicaemia, peritonitis or meningitis.
• Pathophysiology.

Read And Learn More: General Surgery Question and Answers

Presence of gram-positive and gram-negative organisms
↓
Local inflammation occurs
↓
Release of endotoxins from the organism
↓
Activation of neutrophils, monocytes & macrophages.
↓
Release of inflammatory mediators.
↓
Cellular chemotaxis.
↓
Endothelial injury
↓
Activation of the coagulation cascade
↓
Massive fluid loss
↓
Septic shock

Septic Shock Clinical Features:

• Initially, chills and fever above 100 °C occur.

Septic Shock Types:

1. Early warm shock.
   • There is cutaneous vasodilation.
   • Body temperature increases
   • Cutaneous vasodilatation occurs.
   • Arterial blood pressure falls.
   • Cardiac output increases.
   • Skin remains warm, pink and well-perfused.
   • Pulse rate increases
2. Late cold shock.
   • There is increased vascular permeability
   • Cardiac output is decreasing.
   • Hypovolemia occurs.

Septic Shock Treatment:

• Removal of septic focus.
  • Drainage of pus under anaesthesia.
  • Closure of perforation.
  • Resection of gangrene.
• Antibiotics.
  • Administered after antibiotic sensitivity tests.
  • Initial antibiotics are
    • Cephalothin – 6 – 8 gm/day IV in 4 – 6 divided doses.
    • Gentamicin – 5 mg/kg/day.
    • Clindamycin
• Fluid replacement.
  • Crystalloids such as isotonic saline as Ringer’s lactate, may be used.
  • Blood transfusion – to maintain haemoglobin level at 10 mg%.
• Supportive care.
  • Oxygenation.
  • Mechanical ventilation.
  • Endotracheal intubation.
• Steroids.
  • Short-term, high-dose steroid therapy is used.
  • An initial dose of 15 – 30 mg/ kg body weight of methylprednisolone is given.
  • Same dose repeated within 4 hours.
  • Vasoactive drugs.
• Vasodilators such as phenoxybenzamine are used along with fluid replacement.
  • Inotropic agents such as isoproterenol are used to restore adequate circulation.
  • It produces mild peripheral vasodilation.
  • There is a slight fall in BP.

Blood transfusion long answer question

Question 3. Describe the pathophysiology, clinical features and management of haemorrhage or hypovolaemic shock.

Answer:

Haemorrhage shock/Hypovolaemic shock: Such shock occurs due to sudden loss of blood volume or loss of fluid from the vascular space.

Pathophysiology:

Haemorrhage
↓
Loss of blood
↓
Decreased filling of the right heart.
↓
Decreased filling of the pulmonary vasculature
↓
Decreased filling of the left atrium and ventricle
↓
Decrease in stroke volume.
↓
Drop in arterial blood pressure

Hypovolaemic Shock Clinical Features:

• Depending on the degree of blood loss it can be described into three types.

Hypovolaemic Shock Management:

1. Resuscitation.
   • Maintain airway with adequate ventilation and oxygenation.
   • Lower the head with jaw support.
2. Immediate control of bleeding.
   • Raise the foot end of the bed.
   • Use of compression bandages.
3. Extracellular fluid replacement.
   • Ringer’s lactate, Ringer’s acetate or normal saline supplemented with 1-2 ampules of sodium bicarbonate is used.
   • 1000 – 2000 ml solution is given intravenously within 45 minutes.
   • Blood transfusion was done if required.

Question 4. Describe neurogenic shock and its management.

Answer:

Neurogenic Shock Causes:

• Paraplegia.
• Quadriplegia.
• Trauma to spinal cord
• Spinal anaesthesia.

Pathophysiology:

Blockade of the sympathetic nervous system
↓
Loss of arterial and venous tone
↓
Peripheral pooling of blood.
↓
Decrease in cardiac filling
i
Decrease in stroke volume.
↓
Decrease in pulmonary blood volume.
↓
Decrease in cardiac output.
↓
Shock

Neurogenic Shock Clinical Features:

• Skin remains warm, pink and well-perfused.
• Urinary output – normal.
• Heart rate is rapid.
• Blood pressure – decreased

Neurogenic Shock Management:

1. Elevation of the legs to correct peripheral pooling of blood.
2. Fluid administration to increase cardiac output.
3. Use of a vasoconstrictor drug.
   • It increases BP and myocardial activity.

Classification and management of haemorrhage essay

Question 5. Classify haemorrhage and its management, and describe the causes and clinical features. How will you manage a case of primary haemorrhage after a dental extraction?.

Answer:

Haemorrhage: Haemorrhage is defined as the escape of blood from blood vessels.

Haemorrhage Classification:

1. According To The Source:
   • External haemorrhage.
     • Seen externally.
   • Internal haemorrhage.
     • Not seen externally, it is hidden,
     • Example: GIT bleeding.
   • Arterial haemorrhage.
     • It is a haemorrhage coming out of the artery.
     • It is bright red in colour.
   • Venous haemorrhage.
     • It is a haemorrhage coming out of a vein.
     • It is dark red in colour.
   • Capillary haemorrhage.
     • It is a haemorrhage coming out of a capillary
     • It is bright red in color, and it oozes out
2. According To The Time Of Appearance:
   • Primary haemorrhage.
     • Occurs at the time of injury.
   • Reactionary haemorrhage.
     • Occurs within 24 hours of injury.
     • Secondary haemorrhage.
   • Occurs after 7-14 days of injury.

Haemorrhage Management: To Stop Blood Loss.

1. Rest.
   • Use of sedatives and analgesics.
   • Morphine is administered IM/IV.
   • Inj. Pethidine is better than morphine.
2. Position of the patient.
   • The head end of the bed is raised in haemorrhage oc- curing after thyroidectomy.
   • The foot end of the bed is raised in case of haemorrhage from varicose veins.
3. Pressure and packing.
   • Use of sterile gauze pieces and pressure bandage.
   • At home, it can be done with clean linen cloth.
4. Operative methods.
   • Haemorrhage can be controlled by.
     • Use of artery forceps.
     • Ligation of blood vessels.
     • Smaller vessels are coagulated with diathermy.
     • Bigger vessels are sutured
     • In case of oozing blood-following is used
       • Oxycel or gelatine sponge.
       • Gauze soaked in adrenaline (1:1000)
       • Bone wax for bleeding occurring from the bone.

Haemorrhage Causes:

• Bleeding disorders.
• Low platelet count
• Anticoagulant medication.
• Broken or ruptured blood vessels.
• Severe trauma
• After surgery.
• After childbirth.

Haemorrhage Clinical Features:

• Blood loss
• Increased pulse rate
• Thready pulse
• Low blood pressure
• Pallor Restlessness
• Deep respiration
• Cold and calmmy extremities
• Empty veins
• Low urinary output.

Management Of Primary Haemorrhage:

1. Post-Extraction Bleeding.

Removal of clots with gauze
↓
Placement of gauze pad or tea bag over socket.
↓
Patient is instructed to bite over it for 1 hour
↓
Repeated 2-3 times.
↓
Prevent disruption of clot

2. If Bleeding Continues.

Anaesthetise the area
↓
Curette the socket
↓
Remove the existing clot and freshen the bone
↓
Irrigate with normal saline
↓
Place a local haemostatic agent into the socket
↓
Suture under gentle tension

Pathophysiology of shock long essay

Question 6. Describe the indications and complications of blood transfusion.

Answer:

Blood Transfusion: It is the process of transferring blood or blood-based products from one person into the circulatory system of another.

Blood Transfusion Indications:

• Acute haemorrhage – external or internal.
• Certain major operations, like a radical mastectomy.
• In deep burns.
• Preopera is lively in anaemic patients.
• Postoperatively in septicaemia.
• In anaemia.
• In severe malnutrition.
• In coagulation disorders like haemophilia.
• In the treatment of erythroblastosis foetal.
• During chemotherapy for malignant diseases.

Blood Transfusion Complications:

1. Transfusion Reactions:
   • Incompatibility
     • Incompatibility Causes:
       • Incompatible transfusion.
       • Transfusion of hemolyzed blood.
       • Transfusion of old blood.
     • Incompatibility Clinical features:
       • Fever, rigour.
       • Headache.
       • Nausea, vomiting.
       • Pain in the loins.
       • Tingling sensation in the extremities.
       • The feeling of tightness in the chest
       • Dyspnea.
       • Diminished urinary output.
       • Haemoglobinuria.
       • Jaundice
     • Incompatibility Treatment:
       • Stop the transfusion immediately.
       • Administration of 4 fluids.
       • Alkalization of blood with 10 ml of isotonic solution of sodium lactate and simultaneously 10 ml of saturated solution of sodium bicarbonate 4.
       • Use of 80 -120 mg furosemide IV to provoke diuresis.
       • Antihistamine and hydrocortisone may be prescribed.
   • Pyrexia Reactions.
     • Pyrexia Causes:
       • Lack of sterilisation
       • Infected donor’s apparatus
       • Infected blood transfusion,
       • Rapid transfusion,
       • Presence of sulphur compounds in rubber tubing.
     • Pyrexia Clinical Features:
       • Pyrexia.
       • Rigour, chills.
       • Restlessness.
       • Headache.
       • Increased pulse rate.
       • Nausea and vomiting.
     • Pyrexia Treatment:
       • Stop the transfusion immediately.
       • Cover the patient with a blanket.
       • Antipyretic and antihistaminic drugs are injected.
   • Allergic Reaction:
     • Allergic Cause:
       • Allergic reaction to plasma product
     • Allergic Features:
       • Mild tachycardia.
       • Urticarial rash.
       • Fever
       • Dyspnea
       • Circulatory collapse.
     • Allergic Treatment:
       • Stop transfusion
       • Administer 10 mg of chlorpheniramine.
   • Sensitization To Leucocytes And Platelets:
     • Use of antipyretics, antihistamines and steroids.
2. Transmission Of Diseases:
   • Diseases transmitted are.
     • Serum hepatitis
     • AIDS
     • Bacterial infections.
3. Reactions Caused By Massive Transfusion:
   • Acid-base imbalance – alkalosis.
   • Hyperkalaemia.
   • Citrate toxicity.
   • Hypothermia.
   • Failure of coagulation.
4. Complications Of Over-Transfusion:
   • Congestive cardiac failure occurs.
5. Other Complications:
   • Thrombophlebitis
   • Air embolism.

Blood transfusion indications and complications essay

Question 7. Define shock. Describe the pathophysiology and classification of shock. Discuss management of hypovolaemic shock

Answer:

Shock Definition: Shock is a condition in which circulation fails to meet the nutritional needs of the cells and fails to remove the metabolic waste products

Pathophysiology

• Reduced effective volume
  • It may result either
    • By actual loss of blood volume or
    • By decreased cardiac output
• Tissue anoxia
  • Reduction in effective circulating blood volume
  • Reduced venous return
  • Decreased cardiac output
  • Decreased oxygen supply
  • Tissue anoxia
  • Cellular injury
  • Release of inflammatory mediators
  • Results in shock

Shock Classification

• Haematogenic or hypovolaemic shock
• Traumatic shock
• Neurogenic shock
• Cardiogenic shock
• Septic shock
• Miscellaneous
  • Anaphylactic shock

Management Of Hypovolemic Shock

• Resuscitation
  • Maintain airway with adequate ventilation and oxygenation
  • Lower the head with jaw support
• Immediate control of bleeding
  • Raise the foot end of the bed
  • Use of compression bandages
• Extracellular fluid replacement
  • Ringer’s lactate, Ringer’s acetate or normal saline supplemented with 1-2 ampules of sodium bicarbonate is used
  • 1000-2000 ml solution is given within 45 min intravenously
  • Blood transfusion done if required

Principles of transfusion medicine long essay

Question 8. What are blood components? Write in detail about the indications, contraindications and complications of blood transfusion.

Answer:

Blood Components

• There are four main components of blood
  • Plasma
  • Red blood cells or erythrocytes
  • White blood cells or leukocytes
  • Platelets

Blood Transfusion

• Indications
  • Acute haemorrhage
  • Major surgery
  • Deep burns
  • Pre-operative and post-operative in anaemia
  • In malnutrition
  • In coagulation disorders
  • In erythroblastosis fetalis
  • During chemotherapy in malignant diseases
• Contraindications
  • Infections
  • Aortic stenosis
  • Angina
  • Significant cardiac or pulmonary disease
  • Coronary heart disease
  • Cyanotic heart disease
  • Uncontrolled hypertension
• Complications
  • Transfusion reactions
    • Incompatibility
    • Pyrexia reactions
    • Allergic reactions.
  • Transmission of diseases
  • Reactions caused by massive transfusion
    • Acid-base imbalance
    • Hyperkalaemia
    • Citrate toxicity
    • Hypothermia
    • Failure of coagulation
• Complications of over-transfusion
  • Congestive cardiac failure
• Other complications
  • Thrombophlebitis
  • Air embolism