Immunology Complement System Short Essays Question And Answers

Complement System Short Essays

Question 1. Complement system.

Complement system

Complement refers to a system of some non-specific proteins present in normal human and animal serum, which are activated characteristically by antigen-antibody reactions and subsequently lead to a number of biologically significant consequences.

Complement system Components:

There are 9 components of complement: C1, C2, C3, C4, C5, C6, C7, C8andC9.

Complement system Pathways:

There are two pathways through which the complement system acts.

Complement System Complement system Pathways

Complement system Effects of complement:

1. Complement leads to bacteriolysis and cytolysis through membrane damage.

2. C3a and C5a cause degranulation of mast cells to release histamine.

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  • This leads to an inflammatory reaction.

3. Hypersensitivity reaction.

  • Complement participates in type 2 and type 3 hypersensitivity reactions.

4. Endotoxic shock.

  • Excessive C3 activation and platelet adherence lead to endotoxic shock.

5. Immune adherence.

  • Complement bound to antigen-antibody complexes adheres to erythrocytes or to platelets.
  • This is called immune adherence.

6. Opsonisation

  • Complement helps in the destruction of pathogens through opsonization.

7. Autoimmune diseases.

  • Decreased levels of serum complement lead to autoimmune diseases.

Im munology Complement System Celluar Component Of Inflammation

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