Host Modulation Therapy Short Essay Question And Answers

Host Modulation Therapy Short Essays

Question 1. Host Modulation Therapy (HMT).
Answer:

1. Regulation of Immune and Inflammatory re- responses:

Protective mechanism:

• Activation of neutrophils
• Production of antibodies
• Release of TGF-B, IL-4, IL-10, IL-12

Read And Learn More: Periodontics Question and Answers

Destructive mechanism:

• Prolonged bacterial presence
• Release of IL-1, IL-6, TNF-α, PGE2
• Extracellular matrix destruction
• Bone resorption
  • Thus for therapeutic purposes, a protective mechanism is introduced

2. Role of MMPs [Matrix metalloproteinases]:

• Inhibited by…
• A reduced dose of doxycycline (SSD) –
• Subantimicro- by Dose of Doxycycline
• Example: Periostat-20mg BID for 3 months
• It has…
• • No antimicrobial effect
  • Has anti-collagenolytic activity
  • Decreased bone resorption
  • Increases lymphocytes and PMNs

3. Production of Arachidonic acid Metabolites:

• Cyclo-oxygenase
  • Metabolites into
  • Prostaglandin
  • Prostacyclin
  • Thromboxane
• Lipoxygenase
  • Metabolites into
  • Leukotrienes
  • Hydroxyeicosate retinoic acid

4. Regulation of Bone Metabolism Osteoclast:

Host Modulation Therapy Short Question And Answers

Question 1. Periostat.
Answer:

• Periostat is a reduced dose of doxycycline- sub antimicrobial dose of doxycycline
• Periostat is a 20 mg dose of doxycycline
• Indicated as an adjuvant to scaling and root planning in the treatment of chronic periodontitis
• Periostat must not be used as monotherapy because it is based on the sub-antimicrobial dosage of doxycycline
• Periostat is taken twice daily or 3 months, up to a maximum of 9 months of continuous dosing
• Periostat exerts its therapeutic effect through enzyme, cytokine, and osteoclast inhibition

Periostat Effects:

• No antimicrobial effect
• Has anti-collagenolytic activity
• Decreased bone resorption
• Increases lymphocytes and PMNs

Periostat Mechanism:

• Downregulates MMPs
• Reduces cytokine levels
• Upregulates collagen production
• Stimulates osteoblastic activity and new bone formation

Host Modulation Therapy Viva Voce

1. Host modulation therapy restores the balance between pro-inflammatory and anti-inflammatory mediators
2. Host modulation therapy is used as an adjuvant to conventional periodontal therapy
3. Host modulation therapy usually ameliorates excessive or pathologically elevated inflammatory processes
4. Sub antimicrobial dose of Doxycycline is 20 mg
5. Sub antimicrobial dose of Doxycycline can be pre-scribed continuously up to a maximum of 9 months

 

Periodontal Medicine Short Essays

Question 1. Periodontal disease and Coronary Heart disease.
Answer:

• According to cross-sectional studies, myocardial infarction had significantly poor dental conditions. But is independent of the presence of risk factors
• The study of Mattila performed by oral reading- raphy and diagnostic angiography, showed a correlation between the severity of periodontal disease and coronary atheromatous

Periodontal Disease And Coronary Heart Disease Mechanism: