Host Modulation Therapy Short Essays
Question 1. Host Modulation Therapy (HMT).
Answer:
1. Regulation of Immune and Inflammatory re- responses:
Protective mechanism:
- Activation of neutrophils
- Production of antibodies
- Release of TGF-B, IL-4, IL-10, IL-12
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Destructive mechanism:
- Prolonged bacterial presence
- Release of IL-1, IL-6, TNF-α, PGE2
- Extracellular matrix destruction
- Bone resorption
- Thus for therapeutic purposes, a protective mechanism is introduced
2. Role of MMPs [Matrix metalloproteinases]:
- Inhibited by…
- A reduced dose of doxycycline (SSD) –
- Subantimicro- by Dose of Doxycycline
- Example: Periostat-20mg BID for 3 months
- It has…
-
- No antimicrobial effect
- Has anti-collagenolytic activity
- Decreased bone resorption
- Increases lymphocytes and PMNs
3. Production of Arachidonic acid Metabolites:
- Cyclo-oxygenase
- Metabolites into
- Prostaglandin
- Prostacyclin
- Thromboxane
- Lipoxygenase
- Metabolites into
- Leukotrienes
- Hydroxyeicosate retinoic acid
4. Regulation of Bone Metabolism Osteoclast:
Host Modulation Therapy Short Question And Answers
Question 1. Periostat.
Answer:
- Periostat is a reduced dose of doxycycline- sub antimicrobial dose of doxycycline
- Periostat is a 20 mg dose of doxycycline
- Indicated as an adjuvant to scaling and root planning in the treatment of chronic periodontitis
- Periostat must not be used as monotherapy because it is based on the sub-antimicrobial dosage of doxycycline
- Periostat is taken twice daily or 3 months, up to a maximum of 9 months of continuous dosing
- Periostat exerts its therapeutic effect through enzyme, cytokine, and osteoclast inhibition
Periostat Effects:
- No antimicrobial effect
- Has anti-collagenolytic activity
- Decreased bone resorption
- Increases lymphocytes and PMNs
Periostat Mechanism:
- Downregulates MMPs
- Reduces cytokine levels
- Upregulates collagen production
- Stimulates osteoblastic activity and new bone formation
Host Modulation Therapy Viva Voce
- Host modulation therapy restores the balance between pro-inflammatory and anti-inflammatory mediators
- Host modulation therapy is used as an adjuvant to conventional periodontal therapy
- Host modulation therapy usually ameliorates excessive or pathologically elevated inflammatory processes
- Sub antimicrobial dose of Doxycycline is 20 mg
- Sub antimicrobial dose of Doxycycline can be pre-scribed continuously up to a maximum of 9 months
Periodontal Medicine Short Essays
Question 1. Periodontal disease and Coronary Heart disease.
Answer:
- According to cross-sectional studies, myocardial infarction had significantly poor dental conditions. But is independent of the presence of risk factors
- The study of Mattila performed by oral reading- raphy and diagnostic angiography, showed a correlation between the severity of periodontal disease and coronary atheromatous
Periodontal Disease And Coronary Heart Disease Mechanism: