Calcium Channel Blockers Question And Answers

by

Calcium Channel Blockers Important Notes

1. Calcium Channel Blockers Nifedipine

  • It causes relaxation by decreasing the intracellular availability of calcium ions
  • Causes arteriolar dilatation
  • Have a mild effect on veins
  • Do not depress the SA node or AV conduction

Calcium Channel Blockers Short Essays

Question 1. Uses of calcium channel blockers.

Answer:

1. Angina pectoris.

  • Calcium channel blockers [CCB] reduce the frequency and severity of classical and variant angina.

2. Hypertension.

  • CCBs are first-line hypertensive drugs.

3. Arrhythmias

  • Verapamil controls ventricular rate in atrial flutter or fibrillation.

4. Peripheral vascular disease.

  • Used in Raynaud’s disease for its vasodilator effects.

Question 2. Verapamil.

Answer:

Verapamil is a phenylethylamine that acts as are calcium channel blocker.

Verapamil Mechanism:

  • Blocks all types of calcium channels.
  • Inhibits calcium movement inside the cell in the depolarization phase.
  • Inhibits muscle contraction.
  • Decrease calcium currents and calcium entry into cardiac and vascular smooth muscle cells.

Verapamil Actions:

  • Vasodilatation.
  • Cardiac depression.
  • Reduces BP
  • Bradycardia.
  • Reduces AV – conduction.

Question 3. Nifedipine.

Answer:

Nifedipine is a rapidly acting dihydropyridine drug.

Nifedipine Mechanism:

Read And Learn More: Pharmacology Question and Answers

  • Decreases intracellular availability of Ca++.
  • Releases nitric oxide from the vascular endothelium.
  • Inhibits cAMP – phosphodiesterase.
  • Results in raised smooth muscle cAMP.

Nifedipine Uses:

  • Angina pectoris.
  • Hypertension.
  • The alternative in premature labor.

Nifedipine Adverse effects:

  • Flushing, palpitation, headache, ankle edema
  • Hypotension.
  • Increases frequency of angina.
  • Increases urine voiding.

Question 4. Classify calcium channel blockers.

Answer:

calcium channel blockers Classification:

  1. Phenylalkylamines – Verapamil.
  2. Benzothiazepine – Diltiazem.
  3. Dihydropyridine – Nifedipine, Felodipine, Amlodip- ine, Nitrendipine, Lacidipine, Nimodipine.

calcium channel blockers Actions:

  1. Smooth muscle relaxation.
  2. Negative chronotropic, inotropic, and dromotropic action on the heart

Calcium Channel Blockers Short Question And Answers

Question 1. Amlodipine.

Answer:

  1. It is a dihydropyridine calcium channel blocker
  2. It has higher vascular selectivity
  3. It is longer acting drug
  4. It is absorbed very slowly
  5. Used in hypertension

Leave a Comment