Anti Helminitics Question And Answers

Anti Helminitics Short Essays

Question 1. Treatment of hookworm infestations.

Hookworm infections are more common in developing countries.

  • It is seen in people with poor hygiene.
  • It is caused by ancylostoma duodenale and necator americanus.

Hookworm infections Drugs used:

  • Mebendazole and albendazole are used in hookworm infections.

1. Mebendazole:

  • It is broad spectrum antihelmintic.
  • Bioavailability-20 %.
  • Given orally 100 mg BD for 3 days.

Mebendazole Mechanism of action:

  • Binds to b-tubulin with high affinity
  • Inhibits glucose uptake in parasites

Mebendazole Uses:

  • Hookworm infections.
  • Roundworm infections.
  • Trichuriasis.
  • Trichinella spiralis.
  • Hydatid disease.

Read And Learn More: Pharmacology Question and Answers

Mebendazole Adverse effects:

  • Nausea, diarrhea, abdominal pain.
  • Prolonged use causes headaches, fever, alopecia, jaundice, and neutropenia.

2. Albendazole:

  • It is congener of mebendazole.
  • Absorption is Moderate.
  • It is widely distributed in the body.

Albendazole Uses:

  • Trichuriasis.
  • Trichinosis.
  • Tapeworms and strongyloidosis.
  • Neurocysticercosis.
  • Hydatid disease.
  • Filariasis.

Albendazole Adverse effects:

  • Nausea, diarrhea, abdominal pain.
  • Prolonged Use Causes Headache, Fever, Alopecia, Jaundice And Neutropenia.

Anti Helminitics Short Question And Answers

Question 1. Advantages of albendazole over mebendazole.

  • Albendazole is well tolerated.
  • Effective in a single dose
  • Superior to mebendazole in hookworm infections.
  • The active metabolite of albendazole achieves a higher concentration than mebendazole.
  • It also has some activity against T. vaginalis, giardia, lamblia, and Wuchereria bancrofti.

Question 2. Peprlzine citrate.

Paperizine citrate is narrow-spectrum antihelmintic.

Peprlzine citrate Mechanism:

Anti Helminitics Peprizine Citrate Mechanism

Peprlzine citrate Uses:

  • Roundworm infestation.
  • Pinworm infestations.

Peprlzine citrate Adverse effects:

  • Nausea, vomiting, abdominal discomfort, urticaria.
  • At high doses-dizziness, excitement.
  • At toxic doses – produces – convulsions.

Question 3. Uses and adverse effects of Albendazole.

Albendazole Uses:

  • Ascaris
  • Hookworm infections
  • Trichuriasis
  • Tapeworm and strongyloidiasis
  • Neurocysticercosis
  • Hydatid disease
  • Filariasis

Albendazole Adverse effects:

  • Nausea, diarrhea, abdominal pain
  • Prolonged use causes a headache, fever, alopecia, jaundice, and neutropenia

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