Anti Helminitics Question And Answers

Anti Helminitics Short Essays

Question 1. Treatment of hookworm infestations.
Answer:

Hookworm infections are more common in developing countries.

• It is seen in people with poor hygiene.
• It is caused by ancylostoma duodenale and necator americanus.

Hookworm infections Drugs used:

• Mebendazole and albendazole are used in hookworm infections.

1. Mebendazole:

• It is broad spectrum antihelmintic.
• Bioavailability-20 %.
• Given orally 100 mg BD for 3 days.

Mebendazole Mechanism of action:

• Binds to b-tubulin with high affinity
• Inhibits glucose uptake in parasites

Mebendazole Uses:

• Hookworm infections.
• Roundworm infections.
• Trichuriasis.
• Trichinella spiralis.
• Hydatid disease.

Read And Learn More: Pharmacology Question and Answers

Mebendazole Adverse effects:

• Nausea, diarrhea, abdominal pain.
• Prolonged use causes headaches, fever, alopecia, jaundice, and neutropenia.

2. Albendazole:

• It is congener of mebendazole.
• Absorption is Moderate.
• It is widely distributed in the body.

Albendazole Uses:

• Trichuriasis.
• Trichinosis.
• Tapeworms and strongyloidosis.
• Neurocysticercosis.
• Hydatid disease.
• Filariasis.

Albendazole Adverse effects:

• Nausea, diarrhea, abdominal pain.
• Prolonged Use Causes Headache, Fever, Alopecia, Jaundice And Neutropenia.

Anti Helminitics Short Question And Answers

Question 1. Advantages of albendazole over mebendazole.
Answer:

• Albendazole is well tolerated.
• Effective in a single dose
• Superior to mebendazole in hookworm infections.
• The active metabolite of albendazole achieves a higher concentration than mebendazole.
• It also has some activity against T. vaginalis, giardia, lamblia, and Wuchereria bancrofti.

Question 2. Peprlzine citrate.
Answer:

Paperizine citrate is narrow-spectrum antihelmintic.

Peprlzine citrate Mechanism:

Peprlzine citrate Uses:

• Roundworm infestation.
• Pinworm infestations.

Peprlzine citrate Adverse effects:

• Nausea, vomiting, abdominal discomfort, urticaria.
• At high doses-dizziness, excitement.
• At toxic doses – produces – convulsions.

Question 3. Uses and adverse effects of Albendazole.
Answer:

Albendazole Uses:

• Ascaris
• Hookworm infections
• Trichuriasis
• Tapeworm and strongyloidiasis
• Neurocysticercosis
• Hydatid disease
• Filariasis

Albendazole Adverse effects:

• Nausea, diarrhea, abdominal pain
• Prolonged use causes a headache, fever, alopecia, jaundice, and neutropenia